Evidence behind the WHO guidelines: Hospital Care for Children: the usefulness of azole prophylaxis against cryptococcal meningitis in HIV-positive children.
نویسندگان
چکیده
The World Health Organization has produced guidelines for the management of common illnesses in hospitals with limited resources. This series reviews the scientific evidence behind WHO’s recommendations. The WHO guidelines and more reviews are available at http://www.ichrc.org This review addresses the question: The usefulness of azole prophylaxis against cryptococcal meningitis in HIV-positive children. The WHO Pocketbook of Hospital Care for Children recommends that if a HIV positive child has cryptococcal meningitis then treat with amphotericin for 14 days then fluconazole for a further 8 weeks. Fluconazole prophylaxis is then started after treatment. (Pocketbook p. 218)
منابع مشابه
Cryptococcosis in HIV-infected children.
Between January 1994 and December 2001, 21 HIV-infected children were diagnosed as having cryptococcosis. The 8-year point prevalence of cryptococcosis among hospitalized HIV-infected patients was 2.97%. Medical records of 19 patients were available for review. Sixteen patients had cryptococcal meningitis. Of these patients, cryptococcal antigen in the cerebrospinal fluid and sera were positive...
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OBJECTIVES Cryptococcal meningitis is the commonest cause of adult meningitis in Southern Africa. A sizeable proportion of this disease burden is thought to be due to symptomatic relapse of previously treated infection. We carried out a study to examine the contribution of inadequate secondary fluconazole prophylaxis to symptomatic relapses of cryptococcal meningitis. DESIGN A prospective obs...
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عنوان ژورنال:
- Journal of tropical pediatrics
دوره 54 6 شماره
صفحات -
تاریخ انتشار 2008